Details of Bupleurum Formula
Bupleurum unsticks what is stuck.
Bupleurum unsticks what is stuck.

Alternative Names

  • yi gan san
  • Liver-Repressing Powder
  • liver subduing formula
  • i kan san
  • i gan san
  • yoku kan san
  • yokukansan
  • TJ54; TJ-54; TJ 54
  • 抑肝散
  • よくかんさん


  • calms impatience and frequent displays of temper
  • regulates sleeping for those having difficulty falling asleep or staying asleep
  • shoulder pain worse with stress
  • neurosis
  • PMS


Chai Hu 柴胡 hare’s ear root, thorowax root, bupleurum Radix Bupleuri [caution]

Fu Ling 茯苓 sclerotium of tuckahoe, China root, hoelen, Indian bread Poria Cocos

Chuan Xiong 川芎 Sichuan lovage root, cnidium, chuanxiong root Rhizoma Ligustici Chuanxiong

Gan Cao 甘草 licorice root Radix Glycyrrhizae [caution]

Dang Gui 當歸 tangkuei, Chinese angelica root Radix Angelicae Sinensis [supports pregnancy]

Gou Teng 芶藤 stems of gambir vine; gambir, uncaria vine Ramulus Uncariae cum Uncis

Cang Zhu 蒼术 atractylodes rhizome, cang shu Atractylodis Rhizoma

Recommended for these body types:

Slightly Delicate
Slightly Delicate
Recommended for these thermal natures:

<span=”RecommendedDoseSchedule”>Adult Dosage

    Eagle Herbs is now supplying a 2 gram “little spoon”. (Please wash and dry before using.)

    An “average dose” is 10 grams per day of the granules or 20 capsules.

    A Big Dosage for Short-lived but intense issues: 3 little spoons (12 capsules) twice a day.

    A Smaller Dosage for Lingering low-grade concerns: 2 little spoons (8 capsules) twice a day.

    If you are very sensitive to medicines: start out low (1/2 little spoon or 2 capsules) once per day, and raise the dosage each day.

    We find that people find the right dosage for themselves: what feels good for them and they get the results they are looking for.

Your order will last approximately this long:

  • 100 grams powder (capsules or powder): 8 to 25 days
  • 200 grams powder (powder only): 19 to 56 days


Shipping Rate: A

Availability status: in stock

Order Bupleurum Formula
Modified for aches and pains
Anxiety Modification
Stress-Induced Options

5 thoughts on “Bupleurum Formula (yi gan san)”

  1. Yi-gan san has been recommended for treatment of borderline personality disorder. What formula do you offer that would be the same as that reported in the article: “Yigan san for the treatment of borderline personality disorder: an open-label study” by Tsuyshi Miyaoka, et al. in Progress in Neuro-Psychopharmacology and Biological Psychiatry 32 (2008) pages 150-154.

    I can email the article if you can provide an email address.

  2. We have this formula here:
    On the Eagleherbs website we try to keep up with the Japanese names (Yi Gan San= okukansan). In addition the Japanese medical establishment in particular has given them standard designations such as TJ54 to be consistent across languages.
    I can’t comment about the efficacy for borderline personality disorder as that is a pretty broad category. In Chinese medicine, we use it for anger, frustration and to help with headaches.
    thanks for asking,

  3. My GP has suggested that I try TJ-54 to control my restless legs. From reading I deduce I should take about 6 grams daily. Has anyone had any experience using TJ-54 for restless legs?

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